Padova is Italian-American, was born and grew up in Southern California. She graduated from the University of California in Los Angeles with a bachelor’s degree in biochemistry and a bachelor of arts majoring in fine arts. At the end of the university, she studied for four years naturopathy. Padova is a certified Pilates specialist, a yoga and licensed masseur specializing in rehabilitation therapy.
In 2000, Padova first starred in a porno studio Fat Dog Productions in the solo scene, being a virgin. After that she continued to appear in similar scenes from different studios, and three months later she appeared in the first heterosexual scene in the film Extreme Teen 26. The first film in which she performed the anal scene was Penetration Virgins 15: D.P Initiation, where she also performed double penetration.
Gan Padova is the niece of rock musician Ronnie James Dio.